Krueppel-like factor 14 (KLF14)

About Krueppel-like factor 14

Krueppel-like factor 14 (KLF14) is a protein from Homo sapiens identified by UniProt accession Q8TD94, 323 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Krueppel-like factor 14
UniProt accession	Q8TD94
Gene	KLF14
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.46
high density lipoprotein cholesterol measurement · score 0.44
BMI-adjusted leptin measurement · score 0.43
body fat percentage · score 0.43
triglyceride measurement · score 0.43
sex hormone-binding globulin measurement · score 0.43
systolic blood pressure · score 0.41
serum alanine aminotransferase measurement · score 0.40
reticulocyte count · score 0.40
leptin measurement · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TD94-F1	alphafold	PREDICTED	57.01	—

Amino-acid sequence (323 residues)

MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAPPES ALPGPGPPGP ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS WENSGEAPRA SSGFSDPIPC SVQTPCSELA PASGAAAVCA PESSSDAPAV PSAPAAPGAP AASGGFSGGA LGAGPAPAAD QAPRRRSVTP AAKRHQCPFP GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL TSEVESSASG SGPGPAPSFT TCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards