About E3 ubiquitin-protein ligase DTX3L
E3 ubiquitin-protein ligase DTX3L (DTX3L) is a protein
from Homo sapiens identified by UniProt accession
Q8TDB6, 740 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase DTX3L |
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| UniProt accession | Q8TDB6 |
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| Gene | DTX3L |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.34
- neurodegenerative disease · score 0.29
- total cholesterol measurement · score 0.27
- mean corpuscular volume · score 0.10
- mean corpuscular hemoglobin · score 0.09
- sex hormone-binding globulin measurement · score 0.09
- mean corpuscular hemoglobin concentration · score 0.08
- diffuse large B-cell lymphoma · score 0.08
- monocyte count · score 0.08
- melanoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDB6-F1 | alphafold | PREDICTED | 76.90 | — |
Amino-acid sequence (740 residues)
MASHLRPPSP LLVRVYKSGP RVRRKLESYF QSSKSSGGGE CTVSTQEHEA PGTFRVEFSE RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ ISSLTQSQAE TPSGDMHQHE GHIPNAVDSC LQKIFLTVTA DLNCNLFSKE QRAYITTLCP SIRKMEGHDG IEKVCGDFQD IERIHQFLSE QFLESEQKQQ FSPSMTERKP LSQQERDSCI SPSEPETKAE QKSNYFEVPL PYFEYFKYIC PDKINSIEKR FGVNIEIQES SPNMVCLDFT SSRSGDLEAA RESFASEFQK NTEPLKQECV SLADSKQANK FKQELNHQFT KLLIKEKGGE LTLLGTQDDI SAAKQKISEA FVKIPVKLFA ANYMMNVIEV DSAHYKLLET ELLQEISEIE KRYDICSKVS EKGQKTCILF ESKDRQVDLS VHAYASFIDA FQHASCQLMR EVLLLKSLGK ERKHLHQTKF ADDFRKRHPN VHFVLNQESM TLTGLPNHLA KAKQYVLKGG GMSSLAGKKL KEGHETPMDI DSDDSKAASP PLKGSVSSEA SELDKKEKGI CVICMDTISN KKVLPKCKHE FCAPCINKAM SYKPICPTCQ TSYGIQKGNQ PEGSMVFTVS RDSLPGYESF GTIVITYSMK AGIQTEEHPN PGKRYPGIQR TAYLPDNKEG RKVLKLLYRA FDQKLIFTVG YSRVLGVSDV ITWNDIHHKT SRFGGPEMYG YPDPSYLKRV KEELKAKGIE
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