Transcription factor Sp7 (SP7)

About Transcription factor Sp7

Transcription factor Sp7 (SP7) is a protein from Homo sapiens identified by UniProt accession Q8TDD2, 431 residues long. MolForge cross-references it against 0 known binders and 196 disease associations.

Target properties

Protein name	Transcription factor Sp7
UniProt accession	Q8TDD2
Gene	SP7
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (196)

Diseases linked to this target (Open Targets).

osteogenesis imperfecta · score 0.57
Skeletal dysplasia · score 0.37
craniodiaphyseal dysplasia · score 0.37
osteogenesis imperfecta type 4 · score 0.37
heel bone mineral density · score 0.33
alkaline phosphatase measurement · score 0.31
bone density · score 0.28
joint disease · score 0.17
monocyte percentage of leukocytes · score 0.16
bone quantitative ultrasound measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDD2-F1	alphafold	PREDICTED	51.81	—

Amino-acid sequence (431 residues)

MASSLLEEEV HYGSSPLAML TAACSKFGGS SPLRDSTTLG KAGTKKPYSV GSDLSASKTM GDAYPAPFTS TNGLLSPAGS PPAPTSGYAN DYPPFSHSFP GPTGTQDPGL LVPKGHSSSD CLPSVYTSLD MTHPYGSWYK AGIHAGISPG PGNTPTPWWD MHPGGNWLGG GQGQGDGLQG TLPTGPAQPP LNPQLPTYPS DFAPLNPAPY PAPHLLQPGP QHVLPQDVYK PKAVGNSGQL EGSGGAKPPR GASTGGSGGY GGSGAGRSSC DCPNCQELER LGAAAAGLRK KPIHSCHIPG CGKVYGKASH LKAHLRWHTG ERPFVCNWLF CGKRFTRSDE LERHVRTHTR EKKFTCLLCS KRFTRSDHLS KHQRTHGEPG PGPPPSGPKE LGEGRSTGEE EASQTPRPSA SPATPEKAPG GSPEQSNLLE I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards