About RAS guanyl-releasing protein 4
RAS guanyl-releasing protein 4 (RASGRP4) is a protein
from Homo sapiens identified by UniProt accession
Q8TDF6, 673 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | RAS guanyl-releasing protein 4 |
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| UniProt accession | Q8TDF6 |
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| Gene | RASGRP4 |
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| Organism | Homo sapiens |
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| Length | 673 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- basophil count · score 0.42
- eosinophil count · score 0.38
- basophil percentage of leukocytes · score 0.38
- monocyte count · score 0.37
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.29
- eosinophil percentage of leukocytes · score 0.26
- basophil percentage of granulocytes · score 0.24
- sum of eosinophil and basophil counts · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDF6-F1 | alphafold | PREDICTED | 75.85 | — |
Amino-acid sequence (673 residues)
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV MDPPSTASSK LDS
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