Actin-related protein T1 (ACTRT1)

About Actin-related protein T1

Actin-related protein T1 (ACTRT1) is a protein from Homo sapiens identified by UniProt accession Q8TDG2, 376 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Actin-related protein T1
UniProt accession	Q8TDG2
Gene	ACTRT1
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.28
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.07
spermatogenic failure 20 · score 0.06
spermatogenic failure 72 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 27 · score 0.06
spermatogenic failure 51 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDG2-F1	alphafold	PREDICTED	93.06	—

Amino-acid sequence (376 residues)

MFNPHALDVP AVIFDNGSGL CKAGLSGEIG PRHVISSVLG HCKFNVPLAR LNQKYFVGQE ALYKYEALHL HYPIERGLVT GWDDMEKLWK HLFERELGVK PSQQPVLMTE PSLNPREIRE KLAEMMFETF SVPGFYLSNH AVAALYASAC VTGLVVDSGD GVTCTVPIFE GYSLPHAVTK LCMAGRDITE HLTRLLFASG FNFPCILNKA VVNNIKEKLC YIALEPEKEL RKSRGEVLGA YRLPDGHVIH FGDELYQVPE VLFAPDQLGI HSPGLSKMVS SSIMKCDTDI QNKLYADIVL SGGTTLLPGL EERLMKEVEQ LASKGTPIKI TASPDRCFSA WIGASIMTSM SSFKQMWVTS ADFKEYGTSV VQRRCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards