About Transmembrane channel-like protein 1
Transmembrane channel-like protein 1 (TMC1) is a protein
from Homo sapiens identified by UniProt accession
Q8TDI8, 760 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Transmembrane channel-like protein 1 |
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| UniProt accession | Q8TDI8 |
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| Gene | TMC1 |
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| Organism | Homo sapiens |
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| Length | 760 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- autosomal recessive nonsyndromic hearing loss 7 · score 0.72
- deafness · score 0.71
- autosomal dominant nonsyndromic hearing loss 36 · score 0.64
- autosomal dominant nonsyndromic hearing loss · score 0.63
- nonsyndromic genetic hearing loss · score 0.58
- Rare genetic deafness · score 0.55
- hearing loss, autosomal recessive · score 0.51
- Hearing impairment · score 0.46
- balding measurement · score 0.38
- hearing loss · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDI8-F1 | alphafold | PREDICTED | 76.88 | — |
Amino-acid sequence (760 residues)
MSPKKVQIKV EEKEDETEES SSEEEEEVED KLPRRESLRP KRKRTRDVIN EDDPEPEPED EETRKAREKE RRRRLKRGAE EEEIDEEELE RLKAELDEKR QIIATVKCKP WKMEKKIEVL KEAKKFVSEN EGALGKGKGK RWFAFKMMMA KKWAKFLRDF ENFKAACVPW ENKIKAIESQ FGSSVASYFL FLRWMYGVNM VLFILTFSLI MLPEYLWGLP YGSLPRKTVP RAEEASAANF GVLYDFNGLA QYSVLFYGYY DNKRTIGWMN FRLPLSYFLV GIMCIGYSFL VVLKAMTKNI GDDGGGDDNT FNFSWKVFTS WDYLIGNPET ADNKFNSITM NFKEAITEEK AAQVEENVHL IRFLRFLANF FVFLTLGGSG YLIFWAVKRS QEFAQQDPDT LGWWEKNEMN MVMSLLGMFC PTLFDLFAEL EDYHPLIALK WLLGRIFALL LGNLYVFILA LMDEINNKIE EEKLVKANIT LWEANMIKAY NASFSENSTG PPFFVHPADV PRGPCWETMV GQEFVRLTVS DVLTTYVTIL IGDFLRACFV RFCNYCWCWD LEYGYPSYTE FDISGNVLAL IFNQGMIWMG SFFAPSLPGI NILRLHTSMY FQCWAVMCCN VPEARVFKAS RSNNFYLGML LLILFLSTMP VLYMIVSLPP SFDCGPFSGK NRMFEVIGET LEHDFPSWMA KILRQLSNPG LVIAVILVMV LAIYYLNATA KGQKAANLDL KKKMKMQALE NKMRNKKMAA ARAAAAAGRQ
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