About BPI fold-containing family B member 1
BPI fold-containing family B member 1 (BPIFB1) is a protein
from Homo sapiens identified by UniProt accession
Q8TDL5, 484 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | BPI fold-containing family B member 1 |
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| UniProt accession | Q8TDL5 |
|---|
| Gene | BPIFB1 |
|---|
| Organism | Homo sapiens |
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| Length | 484 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (163)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.32
- lung adenocarcinoma · score 0.19
- glioblastoma multiforme · score 0.17
- endometrial cancer · score 0.15
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- early-onset non-syndromic cataract · score 0.09
- BMI-adjusted hip circumference · score 0.09
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDL5-F1 | alphafold | PREDICTED | 87.79 | — |
Amino-acid sequence (484 residues)
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
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