About Sperm acrosome membrane-associated protein 4
Sperm acrosome membrane-associated protein 4 (SPACA4) is a protein
from Homo sapiens identified by UniProt accession
Q8TDM5, 124 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Sperm acrosome membrane-associated protein 4 |
|---|
| UniProt accession | Q8TDM5 |
|---|
| Gene | SPACA4 |
|---|
| Organism | Homo sapiens |
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| Length | 124 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.12
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- azoospermia · score 0.08
- spermatogenic failure 55 · score 0.08
- spermatogenic failure 3 · score 0.08
- spermatogenic failure 7 · score 0.07
- Rare genetic female infertility · score 0.07
- spermatogenic failure 29 · score 0.07
- spermatogenic failure 10 · score 0.07
- spermatogenic failure 11 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDM5-F1 | alphafold | PREDICTED | 81.27 | — |
Amino-acid sequence (124 residues)
MVLCWLLLLV MALPPGTTGV KDCVFCELTD SMQCPGTYMH CGDDEDCFTG HGVAPGTGPV INKGCLRATS CGLEEPVSYR GVTYSLTTNC CTGRLCNRAP SSQTVGATTS LALGLGMLLP PRLL
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