About Potassium voltage-gated channel subfamily V member 2
Potassium voltage-gated channel subfamily V member 2 (KCNV2) is a protein
from Homo sapiens identified by UniProt accession
Q8TDN2, 545 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily V member 2 |
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| UniProt accession | Q8TDN2 |
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| Gene | KCNV2 |
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| Organism | Homo sapiens |
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| Length | 545 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (138)
Diseases linked to this target (Open Targets).
- cone dystrophy with supernormal rod response · score 0.79
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Retinal dystrophy · score 0.56
- cone dystrophy · score 0.49
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- primary progressive multiple sclerosis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDN2-F1 | alphafold | PREDICTED | 75.38 | — |
Amino-acid sequence (545 residues)
MLKQSERRRS WSYRPWNTTE NEGSQHRRSI CSLGARSGSQ ASIHGWTEGN YNYYIEEDED GEEEDQWKDD LAEEDQQAGE VTTAKPEGPS DPPALLSTLN VNVGGHSYQL DYCELAGFPK TRLGRLATST SRSRQLSLCD DYEEQTDEYF FDRDPAVFQL VYNFYLSGVL LVLDGLCPRR FLEELGYWGV RLKYTPRCCR ICFEERRDEL SERLKIQHEL RAQAQVEEAE ELFRDMRFYG PQRRRLWNLM EKPFSSVAAK AIGVASSTFV LVSVVALALN TVEEMQQHSG QGEGGPDLRP ILEHVEMLCM GFFTLEYLLR LASTPDLRRF ARSALNLVDL VAILPLYLQL LLECFTGEGH QRGQTVGSVG KVGQVLRVMR LMRIFRILKL ARHSTGLRAF GFTLRQCYQQ VGCLLLFIAM GIFTFSAAVY SVEHDVPSTN FTTIPHSWWW AAVSISTVGY GDMYPETHLG RFFAFLCIAF GIILNGMPIS ILYNKFSDYY SKLKAYEYTT IRRERGEVNF MQRARKKIAE CLLGSNPQLT PRQEN
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