About Ribonuclease H2 subunit C
Ribonuclease H2 subunit C (RNASEH2C) is a protein
from Homo sapiens identified by UniProt accession
Q8TDP1, 164 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Ribonuclease H2 subunit C |
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| UniProt accession | Q8TDP1 |
|---|
| Gene | RNASEH2C |
|---|
| Organism | Homo sapiens |
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| Length | 164 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- Aicardi-Goutières syndrome · score 0.82
- Aicardi-Goutieres syndrome · score 0.56
- genetic disorder · score 0.41
- neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities · score 0.38
- Abnormality of the nervous system · score 0.34
- platelet count · score 0.19
- Neurodevelopmental disorder · score 0.12
- glomerular filtration rate · score 0.12
- sex hormone-binding globulin measurement · score 0.11
- hair color · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDP1-F1 | alphafold | PREDICTED | 85.22 | — |
Amino-acid sequence (164 residues)
MESGDEAAIE RHRVHLRSAT LRDAVPATLH LLPCEVAVDG PAPVGRFFTP AIRQGPEGLE VSFRGRCLRG EEVAVPPGLV GYVMVTEEKK VSMGKPDPLR DSGTDDQEEE PLERDFDRFI GATANFSRFT LWGLETIPGP DAKVRGALTW PSLAAAIHAQ VPED
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