About TRAF3-interacting protein 1
TRAF3-interacting protein 1 (TRAF3IP1) is a protein
from Homo sapiens identified by UniProt accession
Q8TDR0, 691 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | TRAF3-interacting protein 1 |
|---|
| UniProt accession | Q8TDR0 |
|---|
| Gene | TRAF3IP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 691 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- Senior-Loken syndrome · score 0.75
- neurodegenerative disease · score 0.52
- Jeune syndrome · score 0.42
- short-rib thoracic dysplasia 6 with or without polydactyly · score 0.42
- short rib-polydactyly syndrome, Majewski type · score 0.37
- refractive error measurement · score 0.35
- chronotype measurement · score 0.34
- intraocular pressure measurement · score 0.31
- insomnia measurement · score 0.27
- eye measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TDR0-F1 | alphafold | PREDICTED | 61.93 | — |
Amino-acid sequence (691 residues)
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
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