Probable G-protein coupled receptor 152 (GPR152)

About Probable G-protein coupled receptor 152

Probable G-protein coupled receptor 152 (GPR152) is a protein from Homo sapiens identified by UniProt accession Q8TDT2, 470 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 152
UniProt accession	Q8TDT2
Gene	GPR152
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.06
benign adult familial myoclonic epilepsy · score 0.04
deafness · score 0.04
mean corpuscular volume · score 0.02
mean platelet volume · score 0.02
body height · score 0.02
mean reticulocyte volume · score 0.02
BMI-adjusted waist circumference · score 0.02
mean corpuscular hemoglobin concentration · score 0.02
congenital stationary night blindness · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDT2-F1	alphafold	PREDICTED	70.83	—

Amino-acid sequence (470 residues)

MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA SEGESPSSTP PEAAPGAGPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards