Probable G-protein coupled receptor 148 (GPR148)

About Probable G-protein coupled receptor 148

Probable G-protein coupled receptor 148 (GPR148) is a protein from Homo sapiens identified by UniProt accession Q8TDV2, 347 residues long. MolForge cross-references it against 0 known binders and 2 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 148
UniProt accession	Q8TDV2
Gene	GPR148
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (2)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.25
carcinoma of liver and intrahepatic biliary tract · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDV2-F1	alphafold	PREDICTED	72.76	—

Amino-acid sequence (347 residues)

MGDELAPCPV GTTAWPALIQ LISKTPCMPQ AASNTSLGLG DLRVPSSMLY WLFLPSSLLA AATLAVSPLL LVTILRNQRL RQEPHYLLPA NILLSDLAYI LLHMLISSSS LGGWELGRMA CGILTDAVFA ACTSTILSFT AIVLHTYLAV IHPLRYLSFM SHGAAWKAVA LIWLVACCFP TFLIWLSKWQ DAQLEEQGAS YILPPSMGTQ PGCGLLVIVT YTSILCVLFL CTALIANCFW RIYAEAKTSG IWGQGYSRAR GTLLIHSVLI TLYVSTGVVF SLDMVLTRYH HIDSGTHTWL LAANSEVLMM LPRAMLTYLY LLRYRQLLGM VRGHLPSRRH QAIFTIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards