LIM homeobox transcription factor 1-alpha (LMX1A)

About LIM homeobox transcription factor 1-alpha

LIM homeobox transcription factor 1-alpha (LMX1A) is a protein from Homo sapiens identified by UniProt accession Q8TE12, 382 residues long. MolForge cross-references it against 0 known binders and 292 disease associations.

Target properties

Protein name	LIM homeobox transcription factor 1-alpha
UniProt accession	Q8TE12
Gene	LMX1A
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (292)

Diseases linked to this target (Open Targets).

autosomal dominant nonsyndromic hearing loss 7 · score 0.67
autosomal dominant nonsyndromic hearing loss · score 0.51
BMI-adjusted waist-hip ratio · score 0.39
alcohol consumption measurement · score 0.35
mathematical ability · score 0.34
neurodegenerative disease · score 0.34
Sensorineural hearing impairment · score 0.33
sensorineural hearing loss · score 0.33
brain measurement · score 0.31
cortical thickness · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TE12-F1	alphafold	PREDICTED	68.59	—

Amino-acid sequence (382 residues)

MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards