About Taste receptor type 1 member 2
Taste receptor type 1 member 2 (TAS1R2) is a protein
from Homo sapiens identified by UniProt accession
Q8TE23, 839 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Taste receptor type 1 member 2 |
|---|
| UniProt accession | Q8TE23 |
|---|
| Gene | TAS1R2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 839 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.28
- metabolite measurement · score 0.18
- neurofibrillary tangles measurement · score 0.14
- non-small cell lung carcinoma · score 0.03
- type 2 diabetes mellitus · score 0.02
- dental caries · score 0.02
- alkaline phosphatase measurement · score 0.02
- Obesity · score 0.02
- COVID-19 · score 0.01
- non-alcoholic fatty liver disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE23-F1 | alphafold | PREDICTED | 86.00 | — |
Amino-acid sequence (839 residues)
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD VCYISNNVQP VLYFLAHEDN LLPIQEDYSN YISRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL SRTSQSYTCN QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDKSTC TKRVVYPWQL LEEIWKVNFT LLDHQIFFDP QGDVALHLEI VQWQWDRSQN PFQSVASYYP LQRQLKNIQD ISWHTINNTI PMSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN NEWSYQSETS CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIVCAFK MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLSPTTRTDP DDPKITIVSC NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
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