About Epidermal growth factor receptor kinase substrate 8-like protein 3
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) is a protein
from Homo sapiens identified by UniProt accession
Q8TE67, 593 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Epidermal growth factor receptor kinase substrate 8-like protein 3 |
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| UniProt accession | Q8TE67 |
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| Gene | EPS8L3 |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- hypotrichosis 5 · score 0.40
- Marie Unna hereditary hypotrichosis · score 0.37
- osteitis deformans · score 0.25
- monocyte count · score 0.25
- Thyroid preparation use measurement · score 0.22
- hypothyroidism · score 0.21
- aspartate aminotransferase measurement · score 0.20
- total blood protein measurement · score 0.20
- blood protein measurement · score 0.20
- body height · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE67-F1 | alphafold | PREDICTED | 72.07 | — |
Amino-acid sequence (593 residues)
MSRPSSRAIY LHRKEYSQNL TSEPTLLQHR VEHLMTCKQG SQRVQGPEDA LQKLFEMDAQ GRVWSQDLIL QVRDGWLQLL DIETKEELDS YRLDSIQAMN VALNTCSYNS ILSITVQEPG LPGTSTLLFQ CQEVGAERLK TSLQKALEEE LEQRPRLGGL QPGQDRWRGP AMERPLPMEQ ARYLEPGIPP EQPHQRTLEH SLPPSPRPLP RHTSAREPSA FTLPPPRRSS SPEDPERDEE VLNHVLRDIE LFMGKLEKAQ AKTSRKKKFG KKNKDQGGLT QAQYIDCFQK IKHSFNLLGR LATWLKETSA PELVHILFKS LNFILARCPE AGLAAQVISP LLTPKAINLL QSCLSPPESN LWMGLGPAWT TSRADWTGDE PLPYQPTFSD DWQLPEPSSQ APLGYQDPVS LRRGSHRLGS TSHFPQEKTH NHDPQPGDPN SRPSSPKPAQ PALKMQVLYE FEARNPRELT VVQGEKLEVL DHSKRWWLVK NEAGRSGYIP SNILEPLQPG TPGTQGQSPS RVPMLRLSSR PEEVTDWLQA ENFSTATVRT LGSLTGSQLL RIRPGELQML CPQEAPRILS RLEAVRRMLG ISP
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