About MORC family CW-type zinc finger protein 4
MORC family CW-type zinc finger protein 4 (MORC4) is a protein
from Homo sapiens identified by UniProt accession
Q8TE76, 937 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | MORC family CW-type zinc finger protein 4 |
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| UniProt accession | Q8TE76 |
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| Gene | MORC4 |
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| Organism | Homo sapiens |
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| Length | 937 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.50
- male infertility · score 0.33
- azoospermia, obstructive, with nephrolithiasis · score 0.33
- nephrotic syndrome · score 0.29
- acute pancreatitis · score 0.27
- alcoholic pancreatitis · score 0.25
- chronic pancreatitis · score 0.20
- rheumatic disease · score 0.17
- Macrocephaly · score 0.12
- Intellectual disability, moderate · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE76-F1 | alphafold | PREDICTED | 67.78 | — |
Amino-acid sequence (937 residues)
MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLECVQ AQAVIVPIVP FNQQNKKMII TEDSLPSLEA ILNYSIFNRE NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY DILVSDFDTE EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ VKPTRGEGVG VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW KEKTSQDNFE TSTVARPIPK VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS KAKKQEQTVE EKKKMPMENE NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG EESRSPSLQL KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK DQRQGSLLPE ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG VRDSGAPIQL IPFNREELAE RRKAVESWNP VPYSVASAAI PAAAIGEKAR GYEESEGHNT PKLKNQRELE ELKRTTEKLE RVLAERNLFQ QKVEELEQER NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ ILKAELERTK EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD
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