About Protein phosphatase Slingshot homolog 3
Protein phosphatase Slingshot homolog 3 (SSH3) is a protein
from Homo sapiens identified by UniProt accession
Q8TE77, 659 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Protein phosphatase Slingshot homolog 3 |
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| UniProt accession | Q8TE77 |
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| Gene | SSH3 |
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| Organism | Homo sapiens |
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| Length | 659 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.06
- prostate carcinoma · score 0.06
- high density lipoprotein cholesterol measurement · score 0.04
- myeloid white cell count · score 0.04
- hepatocellular carcinoma · score 0.04
- body height · score 0.04
- BMI-adjusted waist-hip ratio · score 0.04
- hemoglobin measurement · score 0.03
- osteoarthritis · score 0.03
- lean body mass · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE77-F1 | alphafold | PREDICTED | 61.65 | — |
Amino-acid sequence (659 residues)
MALVTVSRSP PGSGASTPVG PWDQAVQRRS RLQRRQSFAV LRGAVLGLQD GGDNDDAAEA SSEPTEKAPS EEELHGDQTD FGQGSQSPQK QEEQRQHLHL MVQLLRPQDD IRLAAQLEAP RPPRLRYLLV VSTREGEGLS QDETVLLGVD FPDSSSPSCT LGLVLPLWSD TQVYLDGDGG FSVTSGGQSR IFKPISIQTM WATLQVLHQA CEAALGSGLV PGGSALTWAS HYQERLNSEQ SCLNEWTAMA DLESLRPPSA EPGGSSEQEQ MEQAIRAELW KVLDVSDLES VTSKEIRQAL ELRLGLPLQQ YRDFIDNQML LLVAQRDRAS RIFPHLYLGS EWNAANLEEL QRNRVTHILN MAREIDNFYP ERFTYHNVRL WDEESAQLLP HWKETHRFIE AARAQGTHVL VHCKMGVSRS AATVLAYAMK QYECSLEQAL RHVQELRPIA RPNPGFLRQL QIYQGILTAS RQSHVWEQKV GGVSPEEHPA PEVSTPFPPL PPEPEGGGEE KVVGMEESQA APKEEPGPRP RINLRGVMRS ISLLEPSLEL ESTSETSDMP EVFSSHESSH EEPLQPFPQL ARTKGGQQVD RGPQPALKSR QSVVTLQGSA VVANRTQAFQ EQEQGQGQGQ GEPCISSTPR FRKVVRQASV HDSGEEGEA
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