About Grainyhead-like protein 3 homolog
Grainyhead-like protein 3 homolog (GRHL3) is a protein
from Homo sapiens identified by UniProt accession
Q8TE85, 626 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | Grainyhead-like protein 3 homolog |
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| UniProt accession | Q8TE85 |
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| Gene | GRHL3 |
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| Organism | Homo sapiens |
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| Length | 626 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- van der Woude syndrome · score 0.72
- Cleft palate · score 0.53
- isolated cleft palate · score 0.52
- genetic disorder · score 0.45
- cleft lip · score 0.37
- van der Woude syndrome 1 · score 0.28
- blood protein measurement · score 0.22
- isolated spina bifida · score 0.10
- psoriasis · score 0.10
- head and neck squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE85-F1 | alphafold | PREDICTED | 60.71 | — |
Amino-acid sequence (626 residues)
MSNELDFRSV RLLKNDPVNL QKFSYTSEDE AWKTYLENPL TAATKAMMRV NGDDDSVAAL SFLYDYYMGP KEKRILSSST GGRNDQGKRY YHGMEYETDL TPLESPTHLM KFLTENVSGT PEYPDLLKKN NLMSLEGALP TPGKAAPLPA GPSKLEAGSV DSYLLPTTDM YDNGSLNSLF ESIHGVPPTQ RWQPDSTFKD DPQESMLFPD ILKTSPEPPC PEDYPSLKSD FEYTLGSPKA IHIKSGESPM AYLNKGQFYP VTLRTPAGGK GLALSSNKVK SVVMVVFDNE KVPVEQLRFW KHWHSRQPTA KQRVIDVADC KENFNTVEHI EEVAYNALSF VWNVNEEAKV FIGVNCLSTD FSSQKGVKGV PLNLQIDTYD CGLGTERLVH RAVCQIKIFC DKGAERKMRD DERKQFRRKV KCPDSSNSGV KGCLLSGFRG NETTYLRPET DLETPPVLFI PNVHFSSLQR SGGAAPSAGP SSSNRLPLKR TCSPFTEEFE PLPSKQAKEG DLQRVLLYVR RETEEVFDAL MLKTPDLKGL RNAISEKYGF PEENIYKVYK KCKRGETSLL HPRLSRHPPP DCLECSHPVT QVRNMGFGDG FWRQRDLDSN PSPTTVNSLH FTVNSE
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