About ATP-dependent RNA helicase homolog DQX1
ATP-dependent RNA helicase homolog DQX1 (DQX1) is a protein
from Homo sapiens identified by UniProt accession
Q8TE96, 717 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase homolog DQX1 |
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| UniProt accession | Q8TE96 |
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| Gene | DQX1 |
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| Organism | Homo sapiens |
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| Length | 717 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.17
- fetal akinesia deformation sequence · score 0.12
- fetal akinesia deformation sequence 1 · score 0.12
- arthrogryposis multiplex congenita · score 0.12
- platelet crit · score 0.11
- Hypervolemia · score 0.09
- IGF-1 measurement · score 0.05
- platelet count · score 0.04
- non-small cell lung carcinoma · score 0.04
- type 2 diabetes mellitus · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TE96-F1 | alphafold | PREDICTED | 87.16 | — |
Amino-acid sequence (717 residues)
MTSQPLRLAE EYGPSPGESE LAVNPFDGLP FSSRYYELLK QRQALPIWAA RFTFLEQLES NPTGVVLVSG EPGSGKSTQI PQWCAEFALA RGFQKGQVTV TQPYPLAARS LALRVADEMD LTLGHEVGYS IPQEDCTGPN TLLRFCWDRL LLQEVASTRG TGAWGVLVLD EAQERSVASD SLQGLLQDAR LEKLPGDLRV VVVTDPALEP KLRAFWGNPP IVHIPREPGE RPSPIYWDTI PPDRVEAACQ AVLELCRKEL PGDVLVFLPS EEEISLCCES LSREVESLLL QGLPPRVLPL HPDCGRAVQA VYEDMDARKV VVTHWLADFS FSLPSIQHVI DSGLELRSVY NPRIRAEFQV LRPISKCQAE ARRLRARGFP PGSCLCLYPK SFLELEAPPL PQPRVCEENL SSLVLLLKRR QIAEPGECHF LDQPAPEALM QALEDLDYLA ALDDDGDLSD LGVILSEFPL APELAKALLA SCEFDCVDEM LTLAAMLTAA PGFTRPPLSA EEAALRRALE HTDGDHSSLI QVYEAFIQSG ADEAWCQARG LNWAALCQAH KLRGELLELM QRIELPLSLP AFGSEQNRRD LQKALVSGYF LKVARDTDGT GNYLLLTHKH VAQLSSYCCY RSRRAPARPP PWVLYHNFTI SKDNCLSIVS EIQPQMLVEL APPYFLSNLP PSESRDLLNQ LREGMADSTA GSKSSSAQEF RDPCVLQ
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