2-phosphoxylose phosphatase 1 (PXYLP1)

About 2-phosphoxylose phosphatase 1

2-phosphoxylose phosphatase 1 (PXYLP1) is a protein from Homo sapiens identified by UniProt accession Q8TE99, 480 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	2-phosphoxylose phosphatase 1
UniProt accession	Q8TE99
Gene	PXYLP1
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.45
leukocyte count · score 0.44
myeloid white cell count · score 0.40
lymphocyte count · score 0.33
neutrophil percentage of leukocytes · score 0.28
granulocyte count · score 0.26
sum of neutrophil and eosinophil counts · score 0.26
sum of basophil and neutrophil counts · score 0.25
monocyte percentage of leukocytes · score 0.24
body height · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TE99-F1	alphafold	PREDICTED	89.30	—

Amino-acid sequence (480 residues)

MLFRNRFLLL LALAALLAFV SLSLQFFHLI PVSTPKNGMS SKSRKRIMPD PVTEPPVTDP VYEALLYCNI PSVAERSMEG HAPHHFKLVS VHVFIRHGDR YPLYVIPKTK RPEIDCTLVA NRKPYHPKLE AFISHMSKGS GASFESPLNS LPLYPNHPLC EMGELTQTGV VQHLQNGQLL RDIYLKKHKL LPNDWSADQL YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF CSGSCYCPVR NQYLEKEQRR QYLLRLKNSQ LEKTYGEMAK IVDVPTKQLR AANPIDSMLC HFCHNVSFPC TRNGCVDMEH FKVIKTHQIE DERERREKKL YFGYSLLGAH PILNQTIGRM QRATEGRKEE LFALYSAHDV TLSPVLSALG LSEARFPRFA ARLIFELWQD REKPSEHSVR ILYNGVDVTF HTSFCQDHHK RSPKPMCPLE NLVRFVKRDM FVALGGSGTN YYDACHREGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards