About Glucose-6-phosphate exchanger SLC37A2
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2) is a protein
from Homo sapiens identified by UniProt accession
Q8TED4, 501 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Glucose-6-phosphate exchanger SLC37A2 |
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| UniProt accession | Q8TED4 |
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| Gene | SLC37A2 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.22
- heel bone mineral density · score 0.21
- atherosclerosis · score 0.04
- Autosomal recessive malignant osteopetrosis · score 0.04
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.04
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.03
- immunodeficiency 89 and autoimmunity · score 0.03
- Testicular regression syndrome · score 0.03
- chronic kidney disease · score 0.03
- neutropenia, severe congenital, 9, autosomal dominant · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TED4-F1 | alphafold | PREDICTED | 83.93 | — |
Amino-acid sequence (501 residues)
MRSSLAPGVW FFRAFSRDSW FRGLILLLTF LIYACYHMSR KPISIVKSRL HQNCSEQIKP INDTHSLNDT MWCSWAPFDK DNYKELLGGV DNAFLIAYAI GMFISGVFGE RLPLRYYLSA GMLLSGLFTS LFGLGYFWNI HELWYFVVIQ VCNGLVQTTG WPSVVTCVGN WFGKGKRGFI MGIWNSHTSV GNILGSLIAG IWVNGQWGLS FIVPGIITAV MGVITFLFLI EHPEDVDCAP PQHHGEPAEN QDNPEDPGNS PCSIRESGLE TVAKCSKGPC EEPAAISFFG ALRIPGVVEF SLCLLFAKLV SYTFLYWLPL YIANVAHFSA KEAGDLSTLF DVGGIIGGIV AGLVSDYTNG RATTCCVMLI LAAPMMFLYN YIGQDGIASS IVMLIICGGL VNGPYALITT AVSADLGTHK SLKGNAKALS TVTAIIDGTG SIGAALGPLL AGLISPTGWN NVFYMLISAD VLACLLLCRL VYKEILAWKV SLSRGSGYKE I
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