About Rho guanine nucleotide exchange factor 40
Rho guanine nucleotide exchange factor 40 (ARHGEF40) is a protein
from Homo sapiens identified by UniProt accession
Q8TER5, 1519 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 40 |
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| UniProt accession | Q8TER5 |
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| Gene | ARHGEF40 |
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| Organism | Homo sapiens |
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| Length | 1519 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.36
- hematocrit · score 0.34
- body height · score 0.34
- hemoglobin measurement · score 0.34
- appendicular lean mass · score 0.34
- neurodegenerative disease · score 0.33
- diet measurement · score 0.32
- testosterone measurement · score 0.29
- erythrocyte count · score 0.29
- PR interval · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TER5-F1 | alphafold | PREDICTED | 62.98 | — |
Amino-acid sequence (1519 residues)
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LICPRFVHKE GLMVGHQPST LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG EYVELLEVTL PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL RPGELRGGGG GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL SPGDKEDASH QEALGNLPSP SEHKLPECHL VKEEYEGSGK PESEPKELKT AGEKEPQLSE ACGPTEEGAG ERELEGPGLL CMAGHTGPEG PLSDTPTPPL ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG GVDQSGRALL TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK RVAKPEELQW ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE LEGAAEPEEE EAVGMPKPLQ KVLADPRLTA LQRDGGAILM RLRSTPSSKL EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ EQRQCLRRLQ QVLQWLSGPG EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE ALALEENATS QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER RIQQHVGEEA SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP RPAPSHCSLA PCGEDYEEEG PELAPEAEGR PPRAVLIRGL EVTSTEVVDR TCSPREHVLL GRARGPDGPW GVGTPRMERK RSISAQQRLV SELIACEQDY VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH FLRELQGCAT HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG RDLLAVEAVR GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF SKLKGPEGGS EMFVYKQAFK TADMGLTENI GDSGLCFELW FRRRRAREAY TLQATSPEIK LKWTSSIAQL LWRQAAHNKE LRVQQMVSMG IGNKPFLDIK ALGERTLSAL LTGRAARTRA SVAVSSFEHA GPSLPGLSPG ACSLPARVEE EAWDLDVKQI SLAPETLDSS GDVSPGPRNS PSLQPPHPGS STPTLASRGI LGLSRQSHAR ALSDPTTPL
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