Fas-binding factor 1 (FBF1)

About Fas-binding factor 1

Fas-binding factor 1 (FBF1) is a protein from Homo sapiens identified by UniProt accession Q8TES7, 1133 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Fas-binding factor 1
UniProt accession	Q8TES7
Gene	FBF1
Organism	Homo sapiens
Length	1133 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.24
mean platelet volume · score 0.24
hypertension · score 0.21
blood pressure · score 0.20
white matter hyperintensity measurement · score 0.20
diastolic blood pressure · score 0.17
platelet count · score 0.17
pulse pressure measurement · score 0.16
body mass index · score 0.12
monocyte count · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TES7-F1	alphafold	PREDICTED	62.59	—

Amino-acid sequence (1133 residues)

MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR TKSLLGDDVF STMAGLEEAD AEVSGISEAD PQALLQAMKD LDGMDADILG LKKSNSAPSK KAAKDPGKGE LPNHPKPAGG AIPTKKSLPS PSSSGHQNRR FSSEDLEDPL RGLLSYDEGG ITKQPPVTQS KTASDKSPST VRDQGPSIPL TPGDTPIRKK EELLFDDGDD IMATLGFGDS PKAEKRQIGD QEGPRPARST LDELLGRGMA TKLLARPGTG EHREFKLDKK YQRPQDSEDM WGDEDFTFGA YQPTVVSSEG RQSRRQSVSR FFADSGADPK GEPGSKQSPP MASSPIQPRK GGADWLGLKD EDLDLFPASP TREAHRESSV PVTPSVPPPA SQHSTPAGLP PSRAKPPTEG AGSPAKASQA SKLRASKEEK EDWLSHALSR KKSQGLAREQ HAGTSEGLHL AGTAGHPPSG SQPLTSTQGL EHAAAGGSSG TTARERPCVR PGVSGSPVTQ NHAASALPTG SPKRGTAPGD LSATEPATCF PSTQKPTEPS VPVQPLLPES LARSLLPSTE YQKQLLAAQV QLQCSPAELQ AELLHSQARL AELEAQVRKL ELERAQHELL LGSLQQQHQA DLELIESAHR SRIKVLETSY QQREERLRRE NEELSARYLS QCQEAEQARA ELTAQHQRRL AAIAQEKDQE MERLRELQRA SILDMRRDHE EQLQRLKLLK DREVDAATSA TSHTRSLNSI IHQMEKFSSS LHELSSRVEA SHLTTSQERE LGIRQRDEQL RALQERLGQQ QRDMEEERSR QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ SKAESMQRAL EEQRKVTAQQ MAMERAELER AKSALLEEQK SVMLKCGEER RRLAAEWAEF SAQQKLSKER AEREAERALQ VDTQREGTLI SLAKQAELKI RASELRAEEK QLAAERAALE QERQELRLEK ERINATALRV KLRAEEVESM SKVASEKYEE GERALREAQQ VQAEQQARLQ AVQQQQERLR KQEQHMHQEH LSLAQQRLQL DRARQDLPSS LVGLFPRAQG PAASSQSALM PPAPTTRWCS QPPTGLDPSP LHLHARLALL RHMAEQDRDF LENEQFFLET LKKGSYNLTS HSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards