About Docking protein 4
Docking protein 4 (DOK4) is a protein
from Homo sapiens identified by UniProt accession
Q8TEW6, 326 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Docking protein 4 |
|---|
| UniProt accession | Q8TEW6 |
|---|
| Gene | DOK4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 326 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- neurodegenerative disease · score 0.16
- mean corpuscular volume · score 0.04
- mean corpuscular hemoglobin concentration · score 0.04
- platelet count · score 0.04
- eosinophil count · score 0.04
- skin disease · score 0.04
- basophil count · score 0.03
- mean corpuscular hemoglobin · score 0.03
- platelet crit · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TEW6-F1 | alphafold | PREDICTED | 74.70 | — |
Amino-acid sequence (326 residues)
MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET DLLNRFILLK PKPSQGDSSE AKTPSQ
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