About Arginine/serine-rich protein PNISR
Arginine/serine-rich protein PNISR (PNISR) is a protein
from Homo sapiens identified by UniProt accession
Q8TF01, 805 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Arginine/serine-rich protein PNISR |
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| UniProt accession | Q8TF01 |
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| Gene | PNISR |
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| Organism | Homo sapiens |
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| Length | 805 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.18
- serum alanine aminotransferase measurement · score 0.14
- creatinine measurement · score 0.14
- metabolite measurement · score 0.05
- depressive symptom measurement · score 0.04
- mathematical ability · score 0.03
- insomnia measurement · score 0.03
- testosterone measurement · score 0.02
- infection · score 0.01
- infect · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF01-F1 | alphafold | PREDICTED | 53.86 | — |
Amino-acid sequence (805 residues)
MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ QSMVEQPPGM MPNGQDMSTM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP PHPPPDQPWM PPTPGPMDIV PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH PPYWQPGPPG PPAPPQNRRE RPSSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL EKMEREKQKK LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEEEDTENV EAASSGKVTR SPSPVPQEEH SDPEMTEEEK EYQMMLLTKM LLTEILLDVT DEEIYYVAKD AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER SDRGSESSDT DDEELRHRIR QKQEAFWRKE KEQQLLHDKQ MEEEKQQTER VTKEMNEFIH KEQNSLSLLE AREADGDVVN EKKRTPNETT SVLEPKKEHK EKEKQGRSRS GSSSSGSSSS NSRTSSTSST VSSSSYSSSS GSSRTSSRSS SPKRKKRHSR SRSPTIKARR SRSRSYSRRI KIESNRARVK IRDRRRSNRN SIERERRRNR SPSRERRRSR SRSRDRRTNR ASRSRSRDRR KIDDQRGNLS GNSHKHKGEA KEQERKKERS RSIDKDRKKK DKEREREQDK RKEKQKREEK DFKFSSQDDR LKRKRESERT FSRSGSISVK IIRHDSRQDS KKSTTKDSKK HSGSDSSGRS SSESPGSSKE KKAKKPKHSR SRSVEKSQRS GKKASRKHKS KSRSR
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