About Serine/threonine-protein phosphatase 4 regulatory subunit 1
Serine/threonine-protein phosphatase 4 regulatory subunit 1 (PPP4R1) is a protein
from Homo sapiens identified by UniProt accession
Q8TF05, 950 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 4 regulatory subunit 1 |
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| UniProt accession | Q8TF05 |
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| Gene | PPP4R1 |
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| Organism | Homo sapiens |
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| Length | 950 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- mathematical ability · score 0.35
- multiple sclerosis · score 0.33
- lysosomal storage disease · score 0.33
- Parkinson disease · score 0.33
- Alzheimer disease · score 0.33
- platelet count · score 0.31
- self reported educational attainment · score 0.27
- mean platelet volume · score 0.26
- cognitive function measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF05-F1 | alphafold | PREDICTED | 73.00 | — |
Amino-acid sequence (950 residues)
MADLSLLQED LQEDADGFGV DDYSSESDVI IIPSALDFVS QDEMLTPLGR LDKYAASENI FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP TVRAELMEQV PHIALFCQEN RPSIPYAFSK FLLPIVVRYL ADQNNQVRKT SQAALLALLE QELIERFDVE TKVCPVLIEL TAPDSNDDVK TEAVAIMCKM APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI CSVVGQQATE EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ YFKEESKSSE EMSVENKNRT RDQEAPEDVQ VRPEDTPSDL SVSNSSVILE NTMEDHAAEA SGKPLGEISV PLDSSLLCTL SSESHQEAAS NENDKKPGNY KSMLRPEVGT TSQDSALLDQ ELYNSFHFWR TPLPEIDLDI ELEQNSGGKP SPEGPEEESE GPVPSSPNIT MATRKELEEM IENLEPHIDD PDVKAQVEVL SAALRASSLD AHEETISIEK RSDLQDELDI NELPNCKINQ EDSVPLISDA VENMDSTLHY IHSDSDLSNN SSFSPDEERR TKVQDVVPQA LLDQYLSMTD PSRAQTVDTE IAKHCAYSLP GVALTLGRQN WHCLRETYET LASDMQWKVR RTLAFSIHEL AVILGDQLTA ADLVPIFNGF LKDLDEVRIG VLKHLHDFLK LLHIDKRREY LYQLQEFLVT DNSRNWRFRA ELAEQLILLL ELYSPRDVYD YLRPIALNLC ADKVSSVRWI SYKLVSEMVK KLHAATPPTF GVDLINELVE NFGRCPKWSG RQAFVFVCQT VIEDDCLPMD QFAVHLMPHL LTLANDRVPN VRVLLAKTLR QTLLEKDYFL ASASCHQEAV EQTIMALQMD RDSDVKYFAS IHPASTKISE DAMSTASSTY
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