Dynein light chain roadblock-type 2 (DYNLRB2)

About Dynein light chain roadblock-type 2

Dynein light chain roadblock-type 2 (DYNLRB2) is a protein from Homo sapiens identified by UniProt accession Q8TF09, 96 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Dynein light chain roadblock-type 2
UniProt accession	Q8TF09
Gene	DYNLRB2
Organism	Homo sapiens
Length	96 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.37
serum alanine aminotransferase measurement · score 0.37
aspartate aminotransferase measurement · score 0.36
refractive error · score 0.30
protein measurement · score 0.26
Myopia · score 0.26
Abnormality of refraction · score 0.26
Age-related cataract · score 0.24
age at onset · score 0.24
sex hormone-binding globulin measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TF09-F1	alphafold	PREDICTED	95.09	—

Amino-acid sequence (96 residues)

MAEVEETLKR IQSHKGVIGT MVVNAEGIPI RTTLDNSTTV QYAGLLHHLT MKAKSTVRDI DPQNDLTFLR IRSKKHEIMV APDKEYLLIV IQNPCE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards