About WASP homolog-associated protein with actin, membranes and microtubules
WASP homolog-associated protein with actin, membranes and microtubules (WHAMM) is a protein
from Homo sapiens identified by UniProt accession
Q8TF30, 809 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | WASP homolog-associated protein with actin, membranes and microtubules |
|---|
| UniProt accession | Q8TF30 |
|---|
| Gene | WHAMM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 809 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.26
- vital capacity · score 0.25
- creatinine measurement · score 0.25
- type 2 diabetes mellitus · score 0.14
- BMI-adjusted hip circumference · score 0.12
- primary ovarian insufficiency · score 0.12
- breast ductal adenocarcinoma · score 0.11
- high density lipoprotein cholesterol measurement · score 0.06
- Osteopenia · score 0.04
- platelet count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF30-F1 | alphafold | PREDICTED | 72.61 | — |
Amino-acid sequence (809 residues)
MEDEQPDSLE GWVPVREGLF AEPERHRLRF LVAWNGAEGK FAVTCHDRTA QQRRLREGAR LGPEPEPKPE AAVSPSSWAG LLSAAGLRGA HRQLAALWPP LERCFPRLPP ELDVGGGGAW GLGLGLWALL WPTRAGPGEA ALQELCGQLE RYLGAAADGC GGATVRDALF PAEGGAADCE SPREFRERAL RARWVEADAR LRQVIQGHGK ANTMVALMNV YQEEDEAYQE LVTVATMFFQ YLLQPFRAMR EVATLCKLDI LKSLDEDDLG PRRVVALEKE AEEWTRRAEE AVVSIQDITV NYFKETVKAL AGMQKEMEQD AKRFGQAAWA TAIPRLEKLQ LMLARETLQL MRAKELCLNH KRAEIQGKME DLPEQEKNTN VVDELEIQFY EIQLELYEVK FEILKNEEIL LTTQLDSLKR LIKEKQDEVV YYDPCENPEE LKVIDCVVGL QDDKNLEVKE LRRQCQQLES KRGRICAKRA SLRSRKDQCK ENHRFRLQQA EESIRYSRQH HSIQMKRDKI KEEEQKKKEW INQERQKTLQ RLRSFKDKRL AQSVRNTSGS EPVAPNLPSD LSQQMCLPAS HAVSVIHPSS RKTRGVPLSE AGNVKSPKCQ NCHGNIPVQV FVPVGDQTHS KSSEELSLPP PPPPPPPPPP PPPPPPPPLR ALSSSSQAAT HQNLGFRAPV KDDQPRPLVC ESPAERPRDS LESFSCPGSM DEVLASLRHG RAPLRKVEVP AVRPPHASIN EHILAAIRQG VKLKKVHPDL GPNPSSKPTS NRRTSDLERS IKAALQRIKR VSADSEEDSD EQDPGQWDG
Explore WASP homolog-associated protein with actin, membranes and microtubules with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets