Zinc finger protein 431 (ZNF431)

About Zinc finger protein 431

Zinc finger protein 431 (ZNF431) is a protein from Homo sapiens identified by UniProt accession Q8TF32, 576 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Zinc finger protein 431
UniProt accession	Q8TF32
Gene	ZNF431
Organism	Homo sapiens
Length	576 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
prostate cancer · score 0.11
esophageal squamous cell carcinoma · score 0.02
oligodendroglioma · score 0.01
astrocytoma · score 0.01
medulloblastoma · score 0.01
primitive neuroectodermal tumor · score 0.01
hyperinsulinemic hypoglycemia, familial, 4 · score 0.00
colorectal cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TF32-F1	alphafold	PREDICTED	70.72	—

Amino-acid sequence (576 residues)

MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE CLNPAQQNLY MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE MVDEPPAMCS YFTKDLWPEQ DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS VDEYKVHKEG YNELNQCLTT TQSKIFPCDK YVKVFHKFLN ANRHKTRHTG KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA FKWFSTLTRH KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD KAFNRFSYLT KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY KCEVCGKAFN ESSNLTTHKM IHTGEKPYKC EECGKAFNRS PQLTAHKIIH TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG EKPYKCEECG KAFNRSSNLT KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY NCEECDNTFN QSSNLIKQNN SYWRETLQMS RMWESL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards