About Zinc finger protein 483
Zinc finger protein 483 (ZNF483) is a protein
from Homo sapiens identified by UniProt accession
Q8TF39, 744 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Zinc finger protein 483 |
|---|
| UniProt accession | Q8TF39 |
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| Gene | ZNF483 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 744 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- age at menarche · score 0.47
- body height · score 0.42
- puberty onset measurement · score 0.41
- apolipoprotein A 1 measurement · score 0.32
- protein measurement · score 0.31
- age at first facial hair · score 0.29
- bone measurement · score 0.28
- age at voice drop · score 0.25
- liver disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF39-F1 | alphafold | PREDICTED | 64.39 | — |
Amino-acid sequence (744 residues)
MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES FRQRFRWFCY SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF LTILPGEIRI WVKSQHPESS EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE NSKEDKMVTV CPNTESCESI TLKDVAVNFS RGEWKKLEPF QKELYKEVLL ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL DESALDKIIE RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK EKTAGEKSRK SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI RRSTLSRRKT PMCEKCRKDS CQEAALNKDE GNESGEKTHK CSKCGKAFGY SASLTKHRRI HTGEKPYMCN ECGKAFSDSS SLTPHHRTHS GEKPFKCDDC GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ HQRIHTGEKP YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL SRHQRIHTGV KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF SRSSILVEHL KIHTGRREYE CNECEKTFKS NSGLIRHRGF HSAE
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