About Zinc finger protein 418
Zinc finger protein 418 (ZNF418) is a protein
from Homo sapiens identified by UniProt accession
Q8TF45, 676 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Zinc finger protein 418 |
|---|
| UniProt accession | Q8TF45 |
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| Gene | ZNF418 |
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| Organism | Homo sapiens |
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| Length | 676 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- genetic disorder · score 0.12
- cardiac hypertrophy · score 0.07
- hepatocellular carcinoma · score 0.07
- gonorrhea · score 0.06
- mean corpuscular volume · score 0.03
- hypertrophic cardiomyopathy · score 0.02
- mean corpuscular hemoglobin · score 0.02
- Dilated cardiomyopathy · score 0.02
- mean corpuscular hemoglobin concentration · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF45-F1 | alphafold | PREDICTED | 70.83 | — |
Amino-acid sequence (676 residues)
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS ECGKSFHRSS SLLRHQRVHT ERSPYK
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