About F-box only protein 41
F-box only protein 41 (FBXO41) is a protein
from Homo sapiens identified by UniProt accession
Q8TF61, 875 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | F-box only protein 41 |
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| UniProt accession | Q8TF61 |
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| Gene | FBXO41 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (184)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- self reported educational attainment · score 0.11
- age at menarche · score 0.07
- Adult-onset autosomal recessive cerebellar ataxia · score 0.06
- Dysequilibrium syndrome · score 0.06
- infantile-onset autosomal recessive nonprogressive cerebellar ataxia · score 0.06
- Spinocerebellar ataxia type 40 · score 0.06
- spinocerebellar ataxia type 35 · score 0.06
- spinocerebellar ataxia type 15/16 · score 0.06
- spinocerebellar ataxia type 37 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TF61-F1 | alphafold | PREDICTED | 67.91 | — |
Amino-acid sequence (875 residues)
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP AAPHLLHHHH HHAPLAHFPG DLVPASLPCE ELAEPGLVPA AAARYALREI EIPLGELFAR KSVASSACST PPPGPGPGPC PGPASASPAS PSPADVAYEE GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE LERKAAELET ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC GSTPSASLGR GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS TGASSRVPAA SQSSGCYDSD SLELPRPEEG APEDSGPGGL GTRAQAANGG SERSQPPRSS GLRRQAIQNW QRRPRRHSTE GEEGDVSDVG SRTTESEAEG PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS RSNEVISPEI LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES LLKAAGGNLL ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH EVIWALGAGC REIVSLQVAP LHPCQQPTRF SNRCLQMIGR CWPHLRALGV GGAGCGVQGL ASLARNCMRL QVLELDHVSE ITQEVAAEVC REGLKGLEML VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS PEAQKLFEDM VTKLQALRRR PGFSKILHIK VEGGC
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