PDZ domain-containing protein GIPC3 (GIPC3)

About PDZ domain-containing protein GIPC3

PDZ domain-containing protein GIPC3 (GIPC3) is a protein from Homo sapiens identified by UniProt accession Q8TF64, 312 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	PDZ domain-containing protein GIPC3
UniProt accession	Q8TF64
Gene	GIPC3
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

deafness · score 0.64
hearing loss, autosomal recessive · score 0.61
Rare genetic deafness · score 0.47
hearing loss · score 0.37
nonsyndromic genetic hearing loss · score 0.37
sensorineural hearing loss · score 0.29
Sensorineural hearing impairment · score 0.29
genetic disorder · score 0.19
Hearing impairment · score 0.17
hemoglobin D disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TF64-F1	alphafold	PREDICTED	84.86	—

Amino-acid sequence (312 residues)

MEGAAAREAR GTETPRASAP PPAPSEPPAA PRARPRLVFR TQLAHGSPTG KIEGFTNVRE LYAKIAEAFG IAPTEILFCT LNSHKVDMQK LLGGQIGLED FIFAHVRGET KEVEVTKTED ALGLTITDNG AGYAFIKRIK EGSIINRIEA VCVGDSIEAI NDHSIVGCRH YEVAKMLREL PKSQPFTLRL VQPKRAFDMI GQRSRSSKCP VEAKVTSGRE TLRLRSGGAA TVEEAPSEFE EEASRKVDDL LESYMGIRDP ELASTMVETS KKTASAQEFA RCLDSVLGEF AFPDEFVVEV WAAIGEAREA CG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards