PDZ domain-containing protein GIPC2 (GIPC2)

About PDZ domain-containing protein GIPC2

PDZ domain-containing protein GIPC2 (GIPC2) is a protein from Homo sapiens identified by UniProt accession Q8TF65, 315 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	PDZ domain-containing protein GIPC2
UniProt accession	Q8TF65
Gene	GIPC2
Organism	Homo sapiens
Length	315 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

body height · score 0.38
body mass index · score 0.38
FEV/FVC ratio · score 0.37
lean body mass · score 0.37
mean corpuscular hemoglobin concentration · score 0.37
reticulocyte count · score 0.37
electrocardiography · score 0.36
Red cell distribution width · score 0.36
fat body mass · score 0.35
appendicular lean mass · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TF65-F1	alphafold	PREDICTED	82.18	—

Amino-acid sequence (315 residues)

MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH GSATGRVEGF SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ LGLEDFIFAH VKGIEKEVNV YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI DSVKTICVGD HIESINGENI VGWRHYDVAK KLKELKKEEL FTMKLIEPKK AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS ETKAKAIEKI DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV FDVWGVIGDA KRRGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards