WAS/WASL-interacting protein family member 2 (WIPF2)

About WAS/WASL-interacting protein family member 2

WAS/WASL-interacting protein family member 2 (WIPF2) is a protein from Homo sapiens identified by UniProt accession Q8TF74, 440 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	WAS/WASL-interacting protein family member 2
UniProt accession	Q8TF74
Gene	WIPF2
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
multiple sclerosis · score 0.35
lysosomal storage disease · score 0.35
Alzheimer disease · score 0.35
Parkinson disease · score 0.35
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
hair color · score 0.16
appendicular lean mass · score 0.13
head and neck squamous cell carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TF74-F1	alphafold	PREDICTED	59.66	—

Amino-acid sequence (440 residues)

MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL KKVTNINDRS APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA KDGSENLAGK PALQIPSSRA AAPRPPVSAA SGRPQDDTDS SRASLPELPR MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR TGPSGQSLAP PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY SFHPVEDFPA PEEYKHFQRI YPSKTNRAAR GAPPLPPILR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards