About Rhodopsin kinase GRK7
Rhodopsin kinase GRK7 (GRK7) is a protein
from Homo sapiens identified by UniProt accession
Q8WTQ7, 553 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Rhodopsin kinase GRK7 |
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| UniProt accession | Q8WTQ7 |
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| Gene | GRK7 |
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| Organism | Homo sapiens |
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| Length | 553 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (29)
Diseases linked to this target (Open Targets).
- Herpes simplex virus 2 seropositivity · score 0.29
- ovarian cancer · score 0.18
- tuberculosis · score 0.14
- susceptibility to Mycobacterium tuberculosis infection measurement · score 0.14
- breast adenocarcinoma · score 0.11
- pro‐interleukin‐16 measurement · score 0.08
- Red cell distribution width · score 0.07
- mean corpuscular hemoglobin · score 0.07
- body height · score 0.06
- adolescent idiopathic scoliosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WTQ7-F1 | alphafold | PREDICTED | 90.22 | — |
Amino-acid sequence (553 residues)
MVDMGALDNL IANTAYLQAR KPSDCDSKEL QRRRRSLALP GLQGCAELRQ KLSLNFHSLC EQQPIGRRLF RDFLATVPTF RKAATFLEDV QNWELAEEGP TKDSALQGLV ATCASAPAPG NPQPFLSQAV ATKCQAATTE EERVAAVTLA KAEAMAFLQE QPFKDFVTSA FYDKFLQWKL FEMQPVSDKY FTEFRVLGKG GFGEVCAVQV KNTGKMYACK KLDKKRLKKK GGEKMALLEK EILEKVSSPF IVSLAYAFES KTHLCLVMSL MNGGDLKFHI YNVGTRGLDM SRVIFYSAQI ACGMLHLHEL GIVYRDMKPE NVLLDDLGNC RLSDLGLAVE MKGGKPITQR AGTNGYMAPE ILMEKVSYSY PVDWFAMGCS IYEMVAGRTP FKDYKEKVSK EDLKQRTLQD EVKFQHDNFT EEAKDICRLF LAKKPEQRLG SREKSDDPRK HHFFKTINFP RLEAGLIEPP FVPDPSVVYA KDIAEIDDFS EVRGVEFDDK DKQFFKNFAT GAVPIAWQEE IIETGLFEEL NDPNRPTGCE EGNSSKSGVC LLL
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