C-type lectin domain family 4 member C (CLEC4C)

About C-type lectin domain family 4 member C

C-type lectin domain family 4 member C (CLEC4C) is a protein from Homo sapiens identified by UniProt accession Q8WTT0, 213 residues long. MolForge cross-references it against 0 known binders and 255 disease associations.

Target properties

Protein name	C-type lectin domain family 4 member C
UniProt accession	Q8WTT0
Gene	CLEC4C
Organism	Homo sapiens
Length	213 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (255)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.33
cutaneous lupus erythematosus · score 0.28
chronic cutaneous lupus erythematosus · score 0.28
blood protein measurement · score 0.25
squamous cell lung carcinoma · score 0.17
glioblastoma multiforme · score 0.17
breast adenocarcinoma · score 0.16
head and neck squamous cell carcinoma · score 0.12
gastric adenocarcinoma · score 0.11
hyper-IgM syndrome type 5 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WTT0-F1	alphafold	PREDICTED	92.04	—

Amino-acid sequence (213 residues)

MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV PQKSICKMKK IYI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards