About Nucleolar complex protein 3 homolog
Nucleolar complex protein 3 homolog (NOC3L) is a protein
from Homo sapiens identified by UniProt accession
Q8WTT2, 800 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Nucleolar complex protein 3 homolog |
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| UniProt accession | Q8WTT2 |
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| Gene | NOC3L |
|---|
| Organism | Homo sapiens |
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| Length | 800 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.39
- neurodegenerative disease · score 0.39
- lysosomal storage disease · score 0.39
- Alzheimer disease · score 0.39
- multiple sclerosis · score 0.39
- systolic blood pressure · score 0.37
- appendicular lean mass · score 0.32
- pulse pressure measurement · score 0.31
- aspartate aminotransferase measurement · score 0.31
- leukocyte count · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WTT2-F1 | alphafold | PREDICTED | 74.83 | — |
Amino-acid sequence (800 residues)
MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM KDLGQRVSFL TRDLSSSEPV HAKKRKHERI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ EEERELEEEI IEDPIQELTI EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR SMLMEQDPDV AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL VALPHFNFHN NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG VIKVISGFVK GRNYEVRPEM LKTFLCLRIK EVEVKKDTED INKPKKFMTF KEKRKSLSRM QRKWKKAEEK LERELREAEA SESTEKKLKL HTETLNIVFV TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV LHTLIESGDL SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR ILMHTFPKTD LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY HPIVQRFAAH LIAGAPSEGS GALKPELSRR SATELFEAYS MAEMTFNPPV ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS SEVATESPLD FTKYLKTSLH
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