About Cytosolic arginine sensor for mTORC1 subunit 1
Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a protein
from Homo sapiens identified by UniProt accession
Q8WTX7, 329 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Cytosolic arginine sensor for mTORC1 subunit 1 |
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| UniProt accession | Q8WTX7 |
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| Gene | CASTOR1 |
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| Organism | Homo sapiens |
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| Length | 329 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.19
- platelet crit · score 0.12
- total cholesterol measurement · score 0.11
- rheumatoid arthritis · score 0.11
- urate measurement · score 0.11
- uric acid measurement · score 0.11
- HbA1c measurement · score 0.10
- platelet count · score 0.09
- eosinophil count · score 0.09
- BMI-adjusted waist-hip ratio · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WTX7-F1 | alphafold | PREDICTED | 88.07 | — |
Amino-acid sequence (329 residues)
MELHILEHRV RVLSVARPGL WLYTHPLIKL LFLPRRSRCK FFSLTETPED YTLMVDEEGF KELPPSEFLQ VAEATWLVLN VSSHSGAAVQ AAGVTKIARS VIAPLAEHHV SVLMLSTYQT DFILVREQDL SVVIHTLAQE FDIYREVGGE PVPVTRDDSS NGFPRTQHGP SPTVHPIQSP QNRFCVLTLD PETLPAIATT LIDVLFYSHS TPKEAASSSP EPSSITFFAF SLIEGYISIV MDAETQKKFP SDLLLTSSSG ELWRMVRIGG QPLGFDECGI VAQIAGPLAA ADISAYYIST FNFDHALVPE DGIGSVIEVL QRRQEGLAS
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