About Serine/threonine-protein kinase 32A
Serine/threonine-protein kinase 32A (STK32A) is a protein
from Homo sapiens identified by UniProt accession
Q8WU08, 396 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase 32A |
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| UniProt accession | Q8WU08 |
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| Gene | STK32A |
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| Organism | Homo sapiens |
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| Length | 396 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (38)
Diseases linked to this target (Open Targets).
- daytime rest measurement · score 0.33
- fibroblast growth factor 23 measurement · score 0.33
- optic cup area measurement · score 0.08
- non-small cell lung carcinoma · score 0.07
- Combined hyperlipidemia · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- hypertriglyceridemia 2 · score 0.04
- hyperinsulinism due to INSR deficiency · score 0.04
- glycogen storage disease VI · score 0.04
- hyperinsulinism due to glucokinase deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WU08-F1 | alphafold | PREDICTED | 87.15 | — |
Amino-acid sequence (396 residues)
MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNL
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