Stromal membrane-associated protein 2 (SMAP2)

About Stromal membrane-associated protein 2

Stromal membrane-associated protein 2 (SMAP2) is a protein from Homo sapiens identified by UniProt accession Q8WU79, 429 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Stromal membrane-associated protein 2
UniProt accession	Q8WU79
Gene	SMAP2
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.39
platelet count · score 0.37
platelet component distribution width · score 0.30
diet measurement · score 0.28
inflammatory bowel disease · score 0.13
lymphocyte count · score 0.11
azoospermia · score 0.10
sitting height measurement · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WU79-F1	alphafold	PREDICTED	62.10	—

Amino-acid sequence (429 residues)

MTGKSVKDVD RYQAVLANLL LEEDNKFCAD CQSKGPRWAS WNIGVFICIR CAGIHRNLGV HISRVKSVNL DQWTQEQIQC MQEMGNGKAN RLYEAYLPET FRRPQIDPAV EGFIRDKYEK KKYMDRSLDI NAFRKEKDDK WKRGSEPVPE KKLEPVVFEK VKMPQKKEDP QLPRKSSPKS TAPVMDLLGL DAPVACSIAN SKTSNTLEKD LDLLASVPSP SSSGSRKVVG SMPTAGSAGS VPENLNLFPE PGSKSEEIGK KQLSKDSILS LYGSQTPQMP TQAMFMAPAQ MAYPTAYPSF PGVTPPNSIM GSMMPPPVGM VAQPGASGMV APMAMPAGYM GGMQASMMGV PNGMMTTQQA GYMAGMAAMP QTVYGVQPAQ QLQWNLTQMT QQMAGMNFYG ANGMMNYGQS MSGGNGQAAN QTLSPQMWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards