Coiled-coil domain-containing protein 12 (CCDC12)

About Coiled-coil domain-containing protein 12

Coiled-coil domain-containing protein 12 (CCDC12) is a protein from Homo sapiens identified by UniProt accession Q8WUD4, 166 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 12
UniProt accession	Q8WUD4
Gene	CCDC12
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.22
HbA1c measurement · score 0.19
neurodegenerative disease · score 0.19
gray platelet syndrome · score 0.18
body height · score 0.18
leukocyte count · score 0.14
monocyte count · score 0.12
basophil count · score 0.11
platelet-to-lymphocyte ratio · score 0.11
neutrophil-to-lymphocyte ratio · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WUD4-F1	alphafold	PREDICTED	75.69	—

Amino-acid sequence (166 residues)

MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL ASAVDAATEQ KTCDSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards