Filamin-binding LIM protein 1 (FBLIM1)

About Filamin-binding LIM protein 1

Filamin-binding LIM protein 1 (FBLIM1) is a protein from Homo sapiens identified by UniProt accession Q8WUP2, 373 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Filamin-binding LIM protein 1
UniProt accession	Q8WUP2
Gene	FBLIM1
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.34
gut microbiome measurement · score 0.25
taxonomic microbiome measurement · score 0.25
neurodegenerative disease · score 0.25
bone quantitative ultrasound measurement · score 0.24
bone density · score 0.21
glioblastoma multiforme · score 0.16
head and neck squamous cell carcinoma · score 0.10
neoplasm · score 0.05
Gollop-Wolfgang complex · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WUP2-F1	alphafold	PREDICTED	66.45	—

Amino-acid sequence (373 residues)

MASKPEKRVA SSVFITLAPP RRDVAVAEEV RQAVCEARRG RPWEAPAPMK TPEAGLAGRP SPWTTPGRAA ATVPAAPMQL FNGGCPPPPP VLDGEDVLPD LDLLPPPPPP PPVLLPSEEE APAPMGASLI ADLEQLHLSP PPPPPQAPAE GPSVQPGPLR PMEEELPPPP AEPVEKGAST DICAFCHKTV SPRELAVEAM KRQYHAQCFT CRTCRRQLAG QSFYQKDGRP LCEPCYQDTL ERCGKCGEVV RDHIIRALGQ AFHPSCFTCV TCARCIGDES FALGSQNEVY CLDDFYRKFA PVCSICENPI IPRDGKDAFK IECMGRNFHE NCYRCEDCRI LLSVEPTDQG CYPLNNHLFC KPCHVKRSAA GCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards