About Short-chain dehydrogenase/reductase family 42E member 1
Short-chain dehydrogenase/reductase family 42E member 1 (SDR42E1) is a protein
from Homo sapiens identified by UniProt accession
Q8WUS8, 393 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Short-chain dehydrogenase/reductase family 42E member 1 |
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| UniProt accession | Q8WUS8 |
|---|
| Gene | SDR42E1 |
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| Organism | Homo sapiens |
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| Length | 393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (76)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.45
- sterol measurement · score 0.28
- mean platelet volume · score 0.15
- inflammatory bowel disease · score 0.12
- coronary artery disease · score 0.10
- total blood protein measurement · score 0.09
- serum non-albumin protein measurement · score 0.09
- blood protein measurement · score 0.09
- C-C motif chemokine 3 measurement · score 0.07
- Fuchs endothelial corneal dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WUS8-F1 | alphafold | PREDICTED | 89.53 | — |
Amino-acid sequence (393 residues)
MDPKRSQKES VLITGGSGYF GFRLGCALNQ NGVHVILFDI SSPAQTIPEG IKFIQGDIRH LSDVEKAFQD ADVTCVFHIA SYGMSGREQL NRNLIKEVNV RGTDNILQVC QRRRVPRLVY TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE QKVLEANATP LDRGDGVLRT CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF KAHGHGRSSG SRDSECFVWD GLLVFLLIIA VLMWLPSSVI LSL
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