About Zinc finger protein 296
Zinc finger protein 296 (ZNF296) is a protein
from Homo sapiens identified by UniProt accession
Q8WUU4, 475 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Zinc finger protein 296 |
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| UniProt accession | Q8WUU4 |
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| Gene | ZNF296 |
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| Organism | Homo sapiens |
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| Length | 475 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (116)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- partial chromosome Y deletion · score 0.06
- primary ovarian insufficiency · score 0.05
- Isolated follicle stimulating hormone deficiency · score 0.05
- spinocerebellar ataxia type 32 · score 0.05
- 46,XX gonadal dysgenesis · score 0.05
- congenital bilateral absence of vas deferens · score 0.05
- partial androgen insensitivity syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WUU4-F1 | alphafold | PREDICTED | 57.36 | — |
Amino-acid sequence (475 residues)
MSRRKAGSAP RRVEPAPAAN PDDEMEMQDL VIELKPEPDA QPQQAPRLGP FSPKEVSSAG RFGGEPHHSP GPMPAGAALL ALGPRNPWTL WTPLTPNYPD RQPWTDKHPD LLTCGRCLQT FPLEAITAFM DHKKLGCQLF RGPSRGQGSE REELKALSCL RCGKQFTVAW KLLRHAQWDH GLSIYQTESE APEAPLLGLA EVAAAVSAVV GPAAEAKSPR ASGSGLTRRS PTCPVCKKTL SSFSNLKVHM RSHTGERPYA CDQCPYACAQ SSKLNRHKKT HRQVPPQSPL MADTSQEQAS AAPPEPAVHA AAPTSTLPCS GGEGAGAAAT AGVQEPGAPG SGAQAGPGGD TWGAITTEQR TDPANSQKAS PKKMPKSGGK SRGPGGSCEF CGKHFTNSSN LTVHRRSHTG ERPYTCEFCN YACAQSSKLN RHRRMHGMTP GSTRFECPHC HVPFGLRATL DKHLRQKHPE AAGEA
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