GATA zinc finger domain-containing protein 1 (GATAD1)

About GATA zinc finger domain-containing protein 1

GATA zinc finger domain-containing protein 1 (GATAD1) is a protein from Homo sapiens identified by UniProt accession Q8WUU5, 269 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	GATA zinc finger domain-containing protein 1
UniProt accession	Q8WUU5
Gene	GATAD1
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

dilated cardiomyopathy 2B · score 0.51
neurodegenerative disease · score 0.49
familial isolated dilated cardiomyopathy · score 0.37
Zellweger spectrum disorders · score 0.34
Zellweger syndrome · score 0.34
Abnormality of the cardiovascular system · score 0.19
dilated cardiomyopathy · score 0.19
heel bone mineral density · score 0.13
bone quantitative ultrasound measurement · score 0.10
bone density · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WUU5-F1	alphafold	PREDICTED	70.56	—

Amino-acid sequence (269 residues)

MPLGLKPTCS VCKTTSSSMW KKGAQGEILC HHCTGRGGAG SGGAGSGAAG GTGGSGGGGF GAATFASTSA TPPQSNGGGG GKQSKQEIHR RSARLRNTKY KSAPAAEKKV STKGKGRRHI FKLKNPIKAP ESVSTIITAE SIFYKGVYYQ IGDVVSVIDE QDGKPYYAQI RGFIQDQYCE KSAALTWLIP TLSSPRDQFD PASYIIGPEE DLPRKMEYLE FVCHAPSEYF KSRSSPFPTV PTRPEKGYIW THVGPTPAIT IKESVANHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards