About Glutathione-specific gamma-glutamylcyclotransferase 2
Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2) is a protein
from Homo sapiens identified by UniProt accession
Q8WUX2, 184 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Glutathione-specific gamma-glutamylcyclotransferase 2 |
|---|
| UniProt accession | Q8WUX2 |
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| Gene | CHAC2 |
|---|
| Organism | Homo sapiens |
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| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (54)
Diseases linked to this target (Open Targets).
- anorexia nervosa · score 0.23
- blood protein measurement · score 0.22
- unipolar depression · score 0.18
- hematocrit · score 0.17
- reticulocyte count · score 0.16
- lymphocyte count · score 0.15
- alcohol drinking · score 0.15
- high density lipoprotein cholesterol measurement · score 0.15
- reticulocyte measurement · score 0.15
- pulse pressure measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WUX2-F1 | alphafold | PREDICTED | 93.51 | — |
Amino-acid sequence (184 residues)
MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
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