Charged multivesicular body protein 7 (CHMP7)

About Charged multivesicular body protein 7

Charged multivesicular body protein 7 (CHMP7) is a protein from Homo sapiens identified by UniProt accession Q8WUX9, 453 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Charged multivesicular body protein 7
UniProt accession	Q8WUX9
Gene	CHMP7
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
viral disease · score 0.46
HIV infection · score 0.46
COVID-19 · score 0.37
severe acute respiratory syndrome · score 0.37
cortical surface area measurement · score 0.21
brain measurement · score 0.21
cortical thickness · score 0.21
breast adenocarcinoma · score 0.18
blood protein measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WUX9-F1	alphafold	PREDICTED	76.01	—

Amino-acid sequence (453 residues)

MWSPEREAEA PAGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD SKMGFWAPLV LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR RGELQRESDF MASVDSSWIS WGVGVFLLKP LKWTLSNMLG DNKVPAEEVL VAVELLKEKA EEVYRLYQNS PLSSHPVVAL SELSTLCANS CPDERTFYLV LLQLQKEKRV TVLEQNGEKI VKFARGPRAK VSPVNDVDVG VYQLMQSEQL LSRKVESLSQ EAERCKEEAR RACRAGKKQL ALRSLKAKQR TEKRIEALHA KLDTVQGILD RIYASQTDQM VFNAYQAGVG ALKLSMKDVT VEKAESLVDQ IQELCDTQDE VSQTLAGGVT NGLDFDSEEL EKELDILLQD TTKEPLDLPD NPRNRHFTNS VPNPRISDAE LEAELEKLSL SEGGLVPSSK SPKRQLEPTL KPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards