About Transmembrane protein 255B
Transmembrane protein 255B (TMEM255B) is a protein
from Homo sapiens identified by UniProt accession
Q8WV15, 326 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Transmembrane protein 255B |
|---|
| UniProt accession | Q8WV15 |
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| Gene | TMEM255B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 326 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (93)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.26
- response to statin · score 0.25
- optic cup area measurement · score 0.17
- total cholesterol measurement · score 0.12
- triglyceride measurement · score 0.11
- cancer · score 0.07
- essential tremor · score 0.06
- low density lipoprotein cholesterol measurement · score 0.06
- Young adult-onset Parkinsonism · score 0.06
- hemoglobin measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WV15-F1 | alphafold | PREDICTED | 70.80 | — |
Amino-acid sequence (326 residues)
MQPPVPGPLG LLDPAEGLSR RKKTSLWFVG SLLLVSVLIV TVGLAATTRT ENVTVGGYYP GIILGFGSFL GIIGINLVEN RRQMLVAAIV FISFGVVAAF CCAIVDGVFA AQHIEPRPLT TGRCQFYSSG VGYLYDVYQT EVTCHSLDGK CQLKVRSNTC YCCDLYACGS AEPSPAYYEF IGVSGCQDVL HLYRLLWASA VLNVLGLFLG IITAAVLGAF KDMVPLSQLA YGPAVPPQTL YNPAQQILAY AGFRLTPEPV PTCSSYPLPL QPCSRFPVAP SSALASSEDL QPPSPSSSGS GLPGQAPPCY APTYFPPGEK PPPYAP
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